////// AURUM SEQUENCE · Research archive · Vol. I

The Compound Library.

Research peptides, catalogued like specimens: what each compound is, how it works, and where the evidence stands today.

Open the catalogue ↓

////// Plate 02 · The specimen

Every compound, catalogued like a specimen.

Structure · Mechanism · Evidence · Status. Documented, cited, dated.

////// The catalogue · Vol. I

Specimens, indexed.

Each entry is a research briefing, not a recommendation. Last reviewed September 2026.

Vol. I

Specimen_01Nº 001 · Metabolic

Retatrutide

GIP · GLP-1 · glucagon receptor triple agonist

One engineered peptide that activates three hormone receptors at once. GLP-1 and GIP signaling drive satiety and insulin response, while glucagon-receptor activity is thought to raise energy expenditure and liver fat oxidation. In a 48-week Phase 2 trial, the highest dose produced a mean weight reduction of about 24%.

Targets: GIPR · GLP-1R · GCGR
Structure: 39-aa peptide, C20 fatty-diacid
Half-life: ≈ 6 days
Status: Investigational · Phase 3

Ref · Jastreboff et al., NEJM 2023 Research use only

Specimen_02Nº 002 · GH axis

Tesamorelin

Growth-hormone-releasing hormone (GHRH) analogue

A stabilized analogue of the body's own GHRH. Rather than supplying growth hormone directly, it signals the pituitary to release GH in its natural pulsatile rhythm, raising IGF-1 downstream. In Phase 3 trials it reduced visceral abdominal fat by roughly 15–18% over 26 weeks, and it has since been studied for liver fat.

Target: GHRH receptor, pituitary
Structure: 44-aa GHRH(1–44), hexenoyl-capped
Half-life: ≈ 26–38 min
Status: FDA-approved 2010 (Egrifta®)

Ref · Falutz et al., NEJM 2007 Research use only

Specimen_03Nº 003 · Pending

Entry in documentation

Being researched, sourced, and cited

The archive grows one carefully documented entry at a time. Get the Starter Guide and you'll hear when the next specimen is catalogued.

Get notified →

Sourced

Every entry is built from primary literature and regulatory labels, and every claim carries its reference.

II.

Dated

Research moves. Each volume shows when it was last reviewed so you know how current it is.

III.

Neutral

No dosing, no promises, no sales pitch. Education for research use only.

////// Correspondence

Letters to the Archive.

Questions, corrections, and requests for the next specimen.

Private · to the archivist

Write a letter

Questions, corrections, sources we missed, or the compound you want catalogued next. Leave an email if you'd like a reply.

Public · reviewed before posting

The reading room

Discuss the entries with other readers. Every comment is reviewed before it appears.

The reading room opens soon.

No dosing questions or sourcing links. They'll be removed. Your email is only used to reply. Research-use education only.